In this context, a partial tumor regression was obtained in the rabbit model by VSV-based vaccines encoding the E6 or UbE6 [62,63] and a potent antitumor effect was induced by administering mice with DNA vaccines encoding HPV-16 E6, E7 and L2 proteins fused to calreticulin [61], some of which are also in clinical trial [64]. This evidence concerns the gene CALR and neoplasm.