In K-M Plot, we found that high BIRC5 expression is associated with poor overall survival in all breast cancers patients (Fig. 2A, p = 0.0002) and in patients with ER+ breast cancer (Fig. 2C, p = 0.03), but was not associated with response in ER− patients (Fig. 2E, p = 0.28). This evidence concerns the gene ESR1 and breast cancer.