EGFR and colorectal carcinoma: EGF receptor (EGFR) pathways implicated in CRC include the RAS/RAF/mitogen-activated protein kinases (MAPK)/Extracellular signal-regulated kinases (ERK) and the phosphatidylinositol 3-kinase (PI3K)/Akt/PTEN/mammalian target of rapamycin (mTOR) pathways, which are involved in the activation of NFκB [13,14].