AR and polycystic ovary syndrome: Although hyperandrogenemia is the trigger for hirsutism, the rate of hair growth is not proportional to the degree of hyperandrogenism [52], supporting a parallel role for androgen receptor localization (keratinocytes, sebaceous glands, and hair dermal papilla cells) and sensitivity in the development of hair patterns and other skin manifestations, such as acne, alopecia, or seborrhea.