INS and polycystic ovary syndrome: The presence of INSR and IGF-1 receptors in TC, GC, and stromal cells of ovarian tissue unequivocally identifies this organ as a target of insulin activity [80], confirmed by observations of decreased steroidogenesis in TC and GC from both healthy and polycystic ovaries, following in vitro administration of both anti-IGF1R and anti-INSR antibodies [81].