In addition, although both obese and nonobese women with PCOS have increased adrenal sensitivity to ACTH for cortisol and androgen secretion [141], the increased ratio of the 11-oxo metabolites of cortisol and corticosterone to their 11-hydroxy metabolites in urine of nonobese PCOS women indicates enhanced oxidation by 11-β–hydroxysteroid dehydrogenase (11-β-HSD) in these subjects. The gene discussed is POMC; the disease is polycystic ovary syndrome.