CDC20 has been found to be overexpressed in many cancer types (Takahashi et al., 1999; Kim et al., 2005b; Iacomino et al., 2006; Ouellet et al., 2006; Kidokoro et al., 2008), which may deregulate activation process of APC and often result in multinucleation, premature anaphase promotion, and mis-segregation of chromosomes, and leads to chromosomal instability and defect in spindle assembly checkpoint response (Mondal et al., 2007; Wang et al., 2013). This evidence concerns the gene APC and cancer.