NME1 and neoplasm: In addition, it has been reported that SET inhibits the DNase activity of the tumor-suppressor NM23-H1 and that the cleavage of SET by Granzyme A during the cytotoxic T lymphocyte-induced apoptosis releases NM23-H1 from inhibition and triggers NM23-H1 to translocate into the nucleus, where it cleaves the DNA (29, 30).