ALK and spindle cell neoplasm: Of particular interest is anaplastic lymphoma kinase or ALK-1 as well as its essential role in differentiating IMT from other spindle cell neoplasms that fall within the broad category of “inflammatory pseudotumors.” According to studies conducted by Lawrence in 2000 and Coffin in 2001, greater than 50% of soft tissue IMTs possess chromosomal translocations involving the short arm of chromosome 2 and the ALK tyrosine kinase receptor locus [16–19, 24].