HMGCR and obesity due to melanocortin 4 receptor deficiency: AT from ob/ob mice exhibits an increase in cholesterol biosynthesis [8], and hypertrophied adipocytes from obesity rodent model, Zucker rats have elevated mRNA expression of SREBP-2, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), and the LDL receptor (LDLR) [9,10].