Examples of loci exhibiting hypermethylation in breast tumor samples relative to normal tissue in promoter CGIs (CIDEA), intragenic CGIs (RASGEF1A), intergenic CGIs (FOXB1), and non-CGI promoters (COL11A1) are presented in Figure 1B (hypermethylated regions are outlined by dashed squares) and in Additional file 1: Figure S2. The gene discussed is COL11A1; the disease is breast neoplasm.