Examples of loci exhibiting hypermethylation in breast tumor samples relative to normal tissue in promoter CGIs (CIDEA), intragenic CGIs (RASGEF1A), intergenic CGIs (FOXB1), and non-CGI promoters (COL11A1) are presented in Figure 1B (hypermethylated regions are outlined by dashed squares) and in Additional file 1: Figure S2. Here, RASGEF1A is linked to breast neoplasm.