Genes with the largest number of pheno-MVPs included ARHGEF16, SIM2, H19, GALNT5, U6, ALG10, IRX4, TBX15, VAX2, and PRRT1 and significantly overlapped with genes showing polycomb-associated H3K27me3 in normal tissue that gained methylation in cancer tissue [49] (P = 9.11 × 10-126; 246 CpGs, identified using GREAT). This evidence concerns the gene SIM2 and cancer.