Local activation of TGF-β may thus be compromised in HHT individuals due to defective interaction between pericytes and endothelial cells affecting mural cell differentiation and vessel stabilization that are typical clinical symptoms of HHT (Torsney et al., 2003; Lebrin et al., 2010; Chen et al., 2013; Tual-Chalot et al., 2014). This evidence concerns the gene TGFB1 and hereditary hemorrhagic telangiectasia.