RAB4A and systemic lupus erythematosus: Epigenetic dysregulation due to methylation/demethylation has been reported in regards to specific genes and autoimmune disorders, such as inability in some lupus patient B lymphocytes to methylate the promoter of the human endogenous retrovirus (HERV) gene, HRES1/p28, leading to its overexpression in lupus (Fali et al., 2014).