The Toll-like receptor 7 (TLR7), located at Xp22.2, has recently been determined to be associated with increased risk for lupus in males in Chinese and Japanese populations when a SNP is found in the 5′ untranslated region (UTR) of the gene (Shen et al., 2010). Here, TLR7 is linked to systemic lupus erythematosus.