Category 2 contains 15 proteins, 9 of which show significant increases in either protein levels or phosphorylation post infection (Histone H3 Di-methyl (Lys9), SAPK/JNK, Cleaved caspase 3-D175, Cleaved caspase 6-D162, Cleaved caspase 7-D198, Cleaved caspase 9-D330 and -D315, p53, Cleaved PARP-D214, and c-Myc) and 6 of which show a significant decrease in phosphorylation (SHP2-Y580, Gab1-Y627, ERK 1/2-T202/Y204, PLC-γ-1-Y783, p38-T180/Y182, and SHIP1-Y1020). The gene discussed is INPP5D; the disease is infection.