DISC1 and major depressive disorder: DISC1 interacts with many other proteins involved in synaptic function, neurodevelopment, the cytoskeleton, and centrosomal pathways, some of which are also associated with schizophrenia and depression (e.g., AKT, DPYSL2, GSK-3β, PDE4, CREB, and β-arrestin) (175–181).