Furthermore, many of the genes targeted in these models have multiple associations; for example, DISC1 is associated with bipolar disorder, major depression, social anhedonia, chronic fatigue syndrome, anxiety, neuroticism, emotional stability, schizophrenia, schizoaffective disorder, and ASD (179, 459, 460). This evidence concerns the gene DISC1 and myalgic encephalomeyelitis/chronic fatigue syndrome.