PLXNB2 expression was increased in all glioma types over normal brain, including oligodendroglioma and astrocytoma (grade II-III), and the highest expression levels were found glioblastoma (grade IV) (Fig. 1D), indicating a correlation of PLXNB2 expression level and glioma grade. The gene discussed is PLXNB2; the disease is central nervous system cancer.