PLXNB2 and central nervous system cancer: However, when we applied a lower threshold for upregulation (>1.25-fold), the proneural subtype showed a statistically significant shorter median survival in the Plexin-B2 upregulated group (Fig. S2B), suggesting that a slight elevation of Plexin-B2 expression may be sufficient to increase the malignant potency of gliomas.