Notwithstanding, in both LN229 and U87MG glioma cells, Sema4C/Plexin-B2 signaling promotes cell migration in vitro, synergistic Met activation, and vascularization of tumor mass, thus underscoring generality of Plexin-B2 function for glioma progression. This evidence concerns the gene PLXNB2 and central nervous system cancer.