SEMA4C and central nervous system cancer: The reduction in actin stress fibers and the increased formation of membrane ruffles by SEMA4C-Fc stimulation were strongly attenuated in Plexin-B2 shRNA knockdown lines, indicating that the Sema4C-triggered actin dynamics in glioma cells are mediated through Plexin-B2 (Fig. 4A; S5A).