Castro Alves et al. [26] found that Slug might act synergistically with Snail and SIP1 in the down-regulation of E-cadherin in 59 gastric carcinomas tissues, and Casas et al. [27] showed that Twist1 and Snail2 acted together to promote EMT and breast tumor metastasis. The gene discussed is TWIST1; the disease is gastric carcinoma.