In accordance with the latter findings, we found that Mcl-1, EZH2, and STMN1 genes were significantly down-regulated following miR-101 overexpression in c-Myc [39] and AKT/Ras [21] mouse HCC cell lines (Supplementary Figure 9), suggesting that these genes are miR-101 targets in mouse liver tumors. Here, AKT1 is linked to hepatocellular carcinoma.