Overall, our NGS study revealed similar mutation frequencies in genes previously analyzed in large DLBCL genomic studies [22, 30, 31] Interestingly, GCB-DLBCL with EZH2 mutations in our cohort showed genomic profiles similar to those previously described for FL, with frequent associated mutations in CREBBP, KMT2D and TNFRSF14, potentially indicating a common genetic history between GCB-EZH2 mutant-DLBCL and FL [23]. This evidence concerns the gene CREBBP and diffuse large B-cell lymphoma.