HOXA9 and central nervous system cancer: Similarly, the transcriptome of HOXA9-silenced U251 cells is significantly associated with genes depleted in glioma stem cells and normal (embryonic, neural and hematopoietic) stem cells (ES = 0.50, FDR = 0.11 and ES = 0.43, FDR = 0.22, respectively; Figure 3C, Supplementary Figure 10C and Supplementary Table 1); in GBML18 cell line, HOXA9-downregulation enriched for genes upregulated during neuronal differentiation and in quiescent chronic myeloid leukemia cells (ES = 0.75, FDR = 0.21 and ES = 0.70, FDR = 0.21, respectively; Figure 3D, Supplementary Figure 10D and Supplementary Table 1).