The fact that HOXA9 transcriptomes were so distinct within GBM cells (U87MG, U251 and GBML18) and in immortalized astrocytes (hTERT/E6/E7) cells suggests that HOXA9 targets different genes in a cell-type dependent manner, which is in accordance with previous reports in leukemia models [19]. This evidence concerns the gene HOXA9 and leukemia.