HOXA9 and glioblastoma: In order to validate the prognostic value of HOXA9 observed in GBM patients (Figure 1E–1G, and [16]), and its relevance in temozolomide chemo-resistance observed in vitro (Figure 6 and Supplementary Figure 11), we established intracranial orthotopic GBM xenografts with U87MG-MSCV and U87MG-HOXA9 cells in nude mice (Figure 7A).