Interestingly, none of these tumor types were positive in our FISH TMA assay (n = 54, n = 14, n = 11, n = 62, n = 23 and n = 10, respectively) indicating that the mechanistic occurrence of TP53 intron 1 rearrangements in the soma is specific for the osteoblast lineage, the believed cell of origin for OS [24]; however, the pro-cancer effect of such rearrangements supports tumor growth in many other tissues. The gene discussed is TP53; the disease is cancer.