Additionally, miR-200a and miR-200b have also been shown to directly target the pro-angiogenic ligands interleukin 8 (IL-8) and chemokine (C-X-C motif) ligand 1 (CXCL1) to regulate angiogenesis in ovarian cancer [50]. The gene discussed is CXCL8; the disease is ovarian carcinoma.