We recently reported that C1GALT1 alters O-glycan structures on MET and enhances MET dimerization in hepatocellular carcinoma [15]; and C1GALT1 modifies O-glycans on FGFR2 and its downstream signaling involved in colorectal cancer malignant phenotypes [16]. This evidence concerns the gene C1GALT1 and hepatocellular carcinoma.