Interestingly, our results are in a part agreement with recent studies, in which two curcumin analogues (H-4073 and FLLL32) [49, 50] were reported to enhance the therapeutic efficacy of cisplatin treatment in HNSCC through the abrogation of STAT3 signaling axis that has also been reported by us recently to be negatively regulated by garcinol [39]. This evidence concerns the gene STAT3 and head and neck squamous cell carcinoma.