MC4R and obesity due to melanocortin 4 receptor deficiency: Other protein traffic diseases potentially benefiting with the development of similar traffic constructs are early-onset severe obesity (caused by mutations in MC4R-melanocortin receptor 4) congenital nephrogenic diabetes insipidus (Aquaporin 2 or Arginine Vasopressin Receptor 242), retinitis pigmentosa (rhodopsin9), Leydig cell hypoplasia (luteinizing hormone receptor10), familial hypercholesterolemia (LDL receptor43) and others44.