The A3AR agonist N6-(3-iodobenzyl)adenosine-5'-N-methyluronamide(IB-MECA) was shown to ameliorate inflammation in two different mouse models of colitis, including DSS-induced colitis and spontaneous colitis found in IL-10-deficient mice18, whereas Ren et al. recently reported that A3AR-deficient mice were less susceptible to DSS-induced colitis17. This evidence concerns the gene IL10 and colitis.