TLR7 and systemic lupus erythematosus: However, the role of TNF-α in MSCs in disease status remains controversial as studies have demonstrated that toll-like receptor 7-stimulated TNF-α caused bone marrow damage in SLE patients [31], and impaired wound healing in animals with diabetes mellitus has been reported to be mediated by abnormal MSCs migration response after TNF-α stimulation [14, 15].