Our results demonstrated that level of HGF mRNA was decreased in SLE BMSCs and were inhibited by both SLE serum and recombinant TNF-α, while the effect was diminished after TNF-α blocking or the presence of TPCA-1, indicating that TNF-α induced impaired migration of SLE BMSCs might be related with inhibition of HGF mRNA production. This evidence concerns the gene TNF and systemic lupus erythematosus.