Compared to healthy controls, TNFRI percentage was increased in SLE BMSCs, and preincubation of SLE BMSCs with TNF-α together with TNFRI neutralizing mAb instead of TNFRII neutralizing mAb significantly converted TNF-α induced impaired SLE BMSCs migration and in vivo homing capacity. The gene discussed is TNF; the disease is systemic lupus erythematosus.