In our experiment, compared to healthy controls, the percentage of TNFRI was increased in SLE BMSCs, while preincubation of BMSCs with TNF-α together with TNFRI neutralizing mAb instead of TNFRII neutralizing mAb significantly restored the capacity of SLE BMSCs migrating and in vivo homing, demonstrating that TNF-α decreased SLE BMSCs migration via a specific TNFRI manner. Here, TNF is linked to systemic lupus erythematosus.