To determine if the diminished clinical presentation of autoimmunity in kirenol treated mice was related to defects in T cells priming, lymphocytes obtained from DLNs were gated on CD4+ T cells, and CD62L, CCR7, CXCR3, CCR6 and CD44high/CD62Llow expression on CD4+ T cells were analyzed by flow cytometry. This evidence concerns the gene CD4 and Autoimmunity.