Remarkably, Ro 48-8071 delivery did not affect the normal vasculature of either exocrine pancreas (Supplementary Figures S2A and S2B) or normal islets (data not shown) in late-stage tumor bearing RIP-Tag2 mice, indicating that OSC inhibition results in a selective impairment of cancer angiogenesis. The gene discussed is LSS; the disease is neoplasm.