Our data suggest that part of the mechanisms by which Ro 48-8071 impairs angiogenesis and, importantly, normalizes tumour vasculature in pancreatic and colon cancers may be due to the impairment of Akt phosphorylation, suggesting that the specific inhibition of PI3K/Akt may represent a new strategy to normalize the tumor vasculature. Here, AKT1 is linked to neoplasm.