Although the recognition of the roles of different enzymes, such as Isocitrate dehydrogenase 1 (IDH1)4, HK25 and Pyruvate kinase M2 (PKM2)6, regulating glucose metabolism helps scientists to better understand the metabolic characteristics of glioma, the molecular mechanisms for glioma metabolic regulation are still not clear. This evidence concerns the gene PKM and glioma.