AKT1 and central nervous system cancer: To be specific, in human glioma, the role of p-AKT on glycolysis is mainly via its regulation on the mitochondria translocation of HK2, which is a key enzyme for glioma energy metabolism and necessary for cell survival under metabolic stress, to mitochondria in glioma cells, resulting in OXPHOX's inhibition and a large amount of lactate production5.