Although there was strong increase of p-PERK in high grade glioma tissues (WHO grade III and IV), the p-PERK level (Figure 1 b) was only slightly elevated in astrocytomas (WHO grade II), which suggested a possible positive correlation between p-PERK level and malignant degree in gliomas (Figure 1 c and Supplementary figure 2), while such a tendency needed to be further confirmed in larger number of tissue samples. Here, EIF2AK3 is linked to central nervous system cancer.