IL12B and inflammatory bowel disease: To further identify whether IL12B genetic polymorphisms would affect the expression levels of IL12p40, we also investigated the polymorphisms of IL12B gene in 812 patients with IBD and 500 healthy controls in the Chinese population, and found that the polymorphisms of IL12B rs6887695 were associated with both CD and UC susceptibility (see supplemental data, Supplemental Digital Content 2, http://links.lww.com/MD/A225, which describes the demographics of IBD patients and controls included in the genotyping analysis and the associations between polymorphisms of IL12B and IBD susceptibility).