CD was generally thought to be characterized as a Th1-mediated immune disorder, whereas UC was considered a Th2-mediated immune disease.49 In order to investigate the potential role of IL12p40 in the regulation of human CD4+ T-cell differentiation, the expression of 4 specific transcript factors mRNA and 4 selected cytokines were identified by real-time PCR and ELISA assay, respectively. Here, CD4 is linked to immune system disorder.