For instance, miR-21 regulates multiple biological processes such as cell proliferation, apoptosis, or tumor invasiveness by targeting PTEN, PDCD4, and RECK in HCC.40 High level of miR-143 expression can promote tumor metastasis by FNDC3B repression.41 MiR-101 promotes the progression of cancer via modulating Mcl-1.42 In the current study, our data indicated that serum miR-10b, miR-106b, and miR-181a showed remarkably high diagnostic accuracy in differentiating HCC cases from healthy controls, and their combinations have an even better performance. This evidence concerns the gene RECK and hepatocellular carcinoma.