Since T-type channels have been implicated in neuronal differentiation [25], and manipulating Cdk5 could be an opportunity to better understand their role during this period, the role of Cdk5 on cyclic adenosine monophosphate (cAMP)-induced differentiation of the neuroblastoma-derived N1E-115 cells was studied using olomoucine (Olo; 50 μM). Here, CDK5 is linked to neuroblastoma.