IGHE and inflammation: Consistent with BML-111-induced downregulation of the TLR2/MyD88/NF-κB pathway, the OVA-induced airway inflammation was restrained, as shown by the reduced serum levels of IL-1β, IL-4 and IL-8, as well as BALF levels of IL-1β, IL-4, IL-8, OVA-IgE.