During the accomplishment of our study Wang et al (12) demonstrated the overexpression of LASP-1 protein in HCC; they showed no correlation between LASP-1 protein expression and liver cirrhosis of HCC patients while they found correlation between cytosolic and nuclear LASP-1 protein expression with hepatitis B surface antigen (HBsAg) of HCC patients. This evidence concerns the gene LASP1 and cirrhosis of liver.