In order to achieve a better accountability in light of the high prevalence of pCHIK rheumatic disorders and global expansion of the virus, we recommend implementation of serology as early as the subacute stage of the disease (i.e. starting at the 3rd week of the disease) to confirm a recent CHIKV infection by the presence of IgM, which is usually detectable until 60 days post-infection [57]. Here, CD40LG is linked to infection.