Based on this context and the results of the study investigating the association between obesity and the sFRP-1 promotion of adipocyte differentiation, the researchers concluded that the association between osteogenesis and adipogenesis is a result of the selective differentiation of BMSC into either osteoblasts or adipocytes, at the expense of the alternative lineage, and that the Wnt signaling pathway is important in regulating the balance between osteoblastogenesis and adipogenesis (41). Here, SFRP1 is linked to obesity due to melanocortin 4 receptor deficiency.