Compared with patients with CD5− DLBCL, CD5+ DLBCL patients are reportedly more often elderly, female, and have >1 ECOG performance status, elevated serum lactate dehydrogenase (LDH) level, advanced stage disease, >1 extranodal sites, B-symptoms, and high International Prognostic Index (IPI) at diagnosis [13, 14, 19]. Here, CD5 is linked to diffuse large B-cell lymphoma.