Moreover, the 48 CD5+ DLBCL patients treated by R-CHOP in this study cohort did not show significant improvement in OS (P= .66) or PFS (P= .81) compared to the 14 CD5+ DLBCL patients treated with CHOP from an independent CHOP-treated DLBCL cohort (results not shown). This evidence concerns the gene DDIT3 and diffuse large B-cell lymphoma.