In addition, TCL1A (which modulates AKT activation downstream of the TCR signaling [39]) and BCL11A (proto-oncogene with a critical role in lymphoid development [40]), which was often co-amplified with REL in lymphoid malignancies [41, 42], were significantly upregulated in CD5+ ABC-DLBC patients (Figures 6B-C). Here, REL is linked to aneurysmal bone cyst.