Compared with previous studies conducted in Japan, CD5+ DLBCL in Western countries had lower prevalence, shared common features of performance status, ABC subtype, Bcl-2 overexpression, BM involvement, and development of CNS recurrence, but lacked features of female predominance, extranodal involvement, elevated serum LDH, and higher disease stage [13-15, 17-19]. This evidence concerns the gene CD5 and diffuse large B-cell lymphoma.