HK2 and urinary bladder cancer: In addition, miR-1 plays a tumor suppressive role via downregulating UCA1 in bladder cancer and UCA1 participates in cancer cell glucose metabolism through the cascade of mTOR-STAT3/miR143-hexokinase 2 (HK2) [21–22], indicating a positive interaction between UCA1 and miRNAs in cancer cells.