In this study, we further elucidate a novel UCA1-miR-216b-FGFR1-ERK signaling pathway regulatory network, that is UCA1 acting as an endogenous sponge to reduce miR-216b expression, resulting in derepression of FGFR1 expression and activation of FGFR1/ERK signaling pathway in HCC (Figure 7D). The gene discussed is FGFR1; the disease is hepatocellular carcinoma.