UCA1 and neoplasm: Ectopic overexpression of miR-216b could suppress cell proliferation, colony formation, migration and invasion and induce G0/G1 cell cycle arrest in HCC cell lines in vitro, as well as inhibit tumor growth in vivo; whereas, upregulation of UCA1 expression could reverse the inhibitory effect of miR-216b on the growth and metastasis of HCC cells in vitro and in vivo (Figure 5).