Mounting evidence shows that FGFR1/ERK cascade plays a crucial role in the carcinogenesis and maintenance of common cancers, and its dysregulation affects the expression of potential downstream targets and crosstalk with other signaling pathways, which are responsible for a wide range of biological processes such as cell proliferation and differentiation, cell cycle and survival, angiogenesis, cell migration and invasion, and so on. Here, FGFR1 is linked to cancer.