After 6-week inoculation, the average weight of tumors developed from miR-216b and pcDNA/UCA1 co-transfected cells (554 ± 26 mg) was obviously larger than those of miR-216b treated group (243 ± 14 mg, Figure 5G), suggesting that UCA1 can invert the inhibition effect of miR-216b on the growth of HCC cells in vivo. This evidence concerns the gene UCA1 and hepatocellular carcinoma.