S100A6 and cancer: In fact, S100A6 has been found elevating in many types of cancers, such as melanoma [10], colorectal adenocarcinomas [11, 12], gastric cancer [13], pancreatic ductal adenocarcinoma [14, 15], astrocytoma [16], papillary thyroid carcinoma [17], choleteatoma [18], and osteosarcoma [19], and its important role in predicting the outcome and the possible therapeutic targets.