S100A6 has been reported to be highly up-regulated in many cancers [10–19], we thus examined the expression in ccRCC tissues and cell lines by quantitative RT-PCR (qRT-PCR) (Figure 1A), western blotting assay (Figure 1B), and immunohistochemical staining (Figure 1C). Here, S100A6 is linked to nonpapillary renal cell carcinoma.