As the microarray and bioinformatics analysis showed knockdown of S100A6 promoted the expression of chemokine, and S100A6 demonstrated direct relation with CXCL14, we detected the expression of CXCL14 in 2 normal kidney cell lines and 4 ccRCC cell lines and found that CXCL14 was widely expressed in normal kidney cells, while barely expressed in tumor cells (Figure 4A). This evidence concerns the gene S100A6 and nonpapillary renal cell carcinoma.