As the microarray and bioinformatics analysis showed knockdown of S100A6 promoted the expression of chemokine, and S100A6 demonstrated direct relation with CXCL14, we detected the expression of CXCL14 in 2 normal kidney cell lines and 4 ccRCC cell lines and found that CXCL14 was widely expressed in normal kidney cells, while barely expressed in tumor cells (Figure 4A). This evidence concerns the gene S100A6 and neoplasm.