In an analysis of mutations of 10 driver genes (EGFR, KRAS, NRAS, HRAS, HER2, BRAF, ALK, PIK3CA, TP53, and LKB1) in 52 lung adenocarcinomas from East Asian never-smokers including 41 women [26], Sun et al. found similar rates of genetic alterations: EGFR mutation in 79% of cases, EML4-ALK fusion in 6% of cases, HER2 mutation in 4% of cases, and KRAS mutation in 2% of cases. This evidence concerns the gene PIK3CA and lung adenocarcinoma.