Adipose tissue expansion during obesity is a potential target to combat obesity and diabetes, therefore to determine if cytosolic thioesterase activity could reduce fatty acid accretion into adipocyte triglyceride to thwart the onset of diet-induced obesity and insulin resistance we expressed Acot7HA in adipose tissue specifically using the Adiponectin-Cre mouse (Acot7HA-Adi). This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.