SCARB1 and Hypocholesterolemia: However, there is no research related to the ability of its leaves to reduce cholesterol levels (hypocholesterolemia) and the mechanism of action of this activity remains uninvestigated, therefore an in vitro study was done to evaluate the mechanism of action of P. macrocarpa leaves extract on reducing cholesterol levels (hypocholesterolemia) by looking at the expression of SR-BI.