Multiple TRIM members involve in antiviral immunity at various levels of the IFN signaling cascade [170, 174]: some TRIMs are IFN inducible and restrict viral infection such as TRIM5, TRIM8, and TRIM22 [175–177], while some TRIMs expressions mediate the production of IFN such as TRIM25, TRIM21, and TRIM68 [174, 178–180]. This evidence concerns the gene TRAT1 and viral infectious disease.