Another important fact in this regard could be the existing divergence in the LPS structure among Gram-negative bacteria and it may be reasonable to presume that TLR-4 respond to certain types of LPS better that TLR-2 while TLR-2 respond better to others [34] resulting in different pathophysiology of the resultant endotoxemia. Here, TLR4 is linked to serum lipopolysaccharide activity.