However, Durmazlar et al. [17] reported that, in 70 untreated patients with BD, the serum levels of TNF-α have strong association with oral ulcer, genital ulcer, the presence of positive pathergy test, and vascular lesion, but no association was found between TNF-α levels and erythema nodosum or arthritis. The gene discussed is TNF; the disease is arthritic joint disease.