To do so, we decided to analyze the relationship between 6 genetic polymorphisms of TNFA (G-308A, C-857T, and C-1031T) as a proinflammatory gene and IL-10 (C-571-A and A-117G) and TGFB (C-509T) as being related to regulatory response and specific sensitization to O. europaea pollen in a well-characterized Spanish population of patients with olive pollen allergy and a high prevalence of asthma (74.7%). This evidence concerns the gene TNF and asthma.