Taking into account all of these previous results, we analyzed the role of 6 polymorphisms of genes previously associated with allergy and asthma, in a population of olive pollen allergic patients, with an extremely high incidence of asthma: TNFA (G-308A, C-857T, and C-1031T) as proinflammatory gene and IL10 (C-571-A and A-117G) and TGFB (C-509T) as genes related to regulatory response. This evidence concerns the gene IL10 and asthma.