PSEN1 and Alzheimer disease: Our longitudinal motor behavioral results showed no significant differences in the ambulatory movement, grip strength, or coordination, addressed by their performance in the rotating rod between APP/PS1 and wild-type mice for any age group studied, in contrast with other treated groups, demonstrating that longitudinal motor assessments of AD transgenic mouse models can provide valuable information with regard to the effect of immunization on the progression of behavioral deficits and overall motor activity.