Findings from tissue-specific injections of Htr1a agonists in rodents suggest that different populations of Htr1a may have opposing roles in anxiety modulation, as agonists injected into the hippocampus or amygdala are anxiogenic, while injections into the raphe are anxiolytic (File et al., 1996; Gonzalez et al., 1996; Akimova et al., 2009). Here, HTR1A is linked to Anxiety.