This, taken together with data showing that genetic suppression of Htr1a expression in serotonin neurons, but not forebrain is sufficient to increase anxiety (Richardson-Jones et al., 2011; Donaldson et al., 2014) and that selective rescue of the receptor in serotonin neurons does not rescue the knockout phenotype (Piszczek et al., 2013), argues for an interaction between forebrain and non-forebrain receptors in regulating this phenotype (Piszczek et al., 2013). Here, HTR1A is linked to Anxiety.