Interestingly, elevated HDAC4 levels have been shown in post mortem HD (Yeh et al., 2013) and FTLD (Frontotemporal Lobar Degeneration) (Whitehouse et al., 2014) brains and HDAC4 has been described as a component of Lewy Bodies in Parkinson's disease brains (Takahashi-Fujigasaki and Fujigasaki, 2006) and of intranuclear inclusions in the neuronal intranuclear inclusion disease (Takahashi-Fujigasaki et al., 2006). Here, HDAC4 is linked to Huntington disease.