Hence, HDAC inhibitors have been recently used in the treatment of a wide-range of brain disorders characterized by pathological alterations in the transcriptome (Fischer et al., 2010) and they have displayed neuroprotective effects in animal models of such neurological disorders like Huntington's disease (HD), Alzheimer's disease (AD) and ischemic stroke. The gene discussed is HDAC9; the disease is Alzheimer disease.