HDAC4 and Huntington disease: Recent findings have increasingly described a widespread peripheral organ pathology in HD, such as skeletal muscles atrophy (Zielonka et al., 2014a) and heart failure (Mielcarek et al., 2014a; Zielonka et al., 2014b), often associated with an increased HDAC4 expression (Mielcarek et al., 2014b).