Here, we used patient-specific induced pluripotent stem cells (iPSCs) derived from an affected member of the Australian DCM family and the corresponding mouse knock-in DCM model (Gramlich et al, 2009) to investigate the potential of AON-mediated exon skipping as a therapeutic strategy to restore titin reading frame (Fig1A) and preserve myocardial function in DCM. The gene discussed is TTN; the disease is familial dilated cardiomyopathy.