Moreover, we observed differences in the subcellular distribution of MURF2, Nbr1, and p62/SQSTM1 in the DCM cardiomyocytes, with an increased number of cells showing a marked nuclear accumulation of MURF2 and a cytosolic, more diffused non-sarcomeric expression of Nbr1 and p62/SQSTM1 (Fig4B). This evidence concerns the gene NBR1 and familial dilated cardiomyopathy.