TTN and familial dilated cardiomyopathy: Importantly, infection with the U7snRNA-TTNAONs-IRES-GFP lentivirus followed by analysis of striated myofibril distribution in GFP+ cardiomyocytes revealed that skipping of TTN exon 326 partially rescued the sarcomere abnormalities of DCM cells, while no effects were observed in the control group or after infection with the U7snRNA-ScrAONs-IRES-GFP virus (Fig3E).