When compared to the control counterpart, a significant down-regulation of α- and β-myosin heavy chain (MYH6 and MYH7) transcripts as well as cardiac α-actin (ACTC1) was measured in the DCM cells untreated or transduced with scrambled AONs (Fig4A). The gene discussed is ACTC1; the disease is familial dilated cardiomyopathy.